Imaging & Therapy
Fluorescence Imaging With an Option of Therapy
Fluorescence imaging of cancer can be achieved with compounds which are tumor-avid and when they absorb appropriate wavelengths of light they fluoresce. For tumor imaging probes it is necessary to have a significant shift (>20 nm) between the absorption and fluorescence wavelengths. Photolitec technology includes certain tumor-avid near-infrared (NIR) agents with desired photophysical properties. The target-specificity has been achieved by attaching certain target-specific molecules to these fluorophores. Conjugates (PL-523) obtained by linking these fluorophores shows excellent tumor-imaging and PDT efficacy. Insertion of an appropriate metal in the PS of the PS-fluorophore conjugates reduced the fluorescence resonance energy transfer (FRET) between the two moieties and enhanced its singlet oxygen producing ability and PDT efficacy. Photolitec technology provides excellent candidates for fluorescence-imaging, image-guided PDT and monitoring the long-term tumor cure.
A Novel Approach to a Bifunctional Photosensitizer for Tumor Imaging and Phototherapy
Compared to Purpurinimides, the Pyropheophorbide Containing an Iodobenzyl Group Showed Enhanced PDT Efficacy and Tumor Imaging (124I-PET) Ability
Synthesis, Photophysical, Electrochemical, Tumor-Imaging, and Phototherapeutic Properties of Purpurinimide-N-substituted Cyanine Dyes Joined with Variable Lengths of Linkers