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Cancer Therapy

Photodynamic Therapy

Tumor Targeted Photosensitizers

Long Wavelength Photosensitizers

Imaging & Therapy

PET / Fluorescence

Fluorescence

Nanotechnology

Nanotechnology

 

Related Publications

Fluorescence Imaging With an Option of Therapy

Fluorescence imaging of cancer can be achieved with compounds which are tumor-avid and when they absorb appropriate wavelengths of light they fluoresce. For tumor imaging probes it is necessary to have a significant shift (>20 nm) between the absorption and fluorescence wavelengths. Photolitec technology includes certain tumor-avid near-infrared (NIR) agents with desired photophysical properties. The target-specificity has been achieved by attaching certain target-specific molecules to these fluorophores. Conjugates (PL-523) obtained by linking these fluorophores shows excellent tumor-imaging and  PDT efficacy. Insertion of an appropriate metal in the PS of the PS-fluorophore conjugates reduced the fluorescence resonance energy transfer (FRET) between the two moieties and enhanced its singlet oxygen producing ability and PDT efficacy. Photolitec technology provides excellent candidates for fluorescence-imaging, image-guided PDT and monitoring the long-term tumor cure.

 

Related Publications

A Novel Approach to a Bifunctional Photosensitizer for Tumor Imaging and Phototherapy
Yihui Chen, Amy Gryshuk, Samuel Achilefu, Tymish Ohulchansky, William Potter, Tuoxiu Zhong, Janet Morgan, Britton Chance, Paras N. Prasad, Barbara W. Henderson, Allan Oseroff, and Ravindra K. Pandey
Bioconjugate Chem. 2005, 16, 1264-1274
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Compared to Purpurinimides, the Pyropheophorbide Containing an Iodobenzyl Group Showed Enhanced PDT Efficacy and Tumor Imaging (124I-PET) Ability
Suresh K. Pandey, Munawwar Sajjad, Yihui Chen, Anupam Pandey, Joseph R. Misser, Carrie Batt, Rutao Yao, Hani A. Nabi, Allan R. Oseroff, and Ravindra K. Pandey
Bioconjugate Chem. 2009, 20, 274–282
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Synthesis, Photophysical, Electrochemical, Tumor-Imaging, and Phototherapeutic Properties of Purpurinimide-N-substituted Cyanine Dyes Joined with Variable Lengths of Linkers
Michael P. A. Williams, Manivannan Ethirajan, Kei Ohkubo, Ping Chen, Paula Pera, Janet Morgan, William H. White, III, Masayuki Shibata, Shunichi Fukuzumi, Karl M. Kadish, and Ravindra K. Pandey
Bioconjugate Chem. 2011, A-M
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